Nortriptyline, Pregabalin & Methylcobalamin Tablets

Description

MAV-NT is a triple-combination neuropathic pain tablet offered by Senen Biotech. Nortriptyline, Pregabalin and Methylcobalamin Tablet combines three clinically proven molecules — Pregabalin 75mg (Sustained Release), Nortriptyline 10mg, and Methylcobalamin 1500mcg — into a single, convenient fixed-dose tablet designed to deliver comprehensive relief from neuropathic pain and nerve damage.

This formulation is one of the most prescribed neuropathic pain combinations in India today, with a strong and growing prescription base across neurology, orthopaedics, diabetology, and general medicine. Available in a standard 10×10 blister pack, MAV-NT is for PCD pharma franchise partners who want to add a high-demand, premium-value neuro-ortho product to their portfolio with excellent doctor acceptance and consistent market demand.

Understanding the Triple-Action Mechanism of MAV-NT

What makes MAV-NT uniquely effective is that each of its three active molecules targets neuropathic pain and nerve damage through a different and complementary biological pathway — making the combination significantly more powerful than any single drug used alone.

Pregabalin 75mg (Sustained Release) — The Nerve Pain Blocker

Pregabalin is a second-generation anticonvulsant and the gold-standard molecule for neuropathic pain management. It works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in hyperactive nerve cells. This binding reduces the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P — the chemical messengers that carry pain signals through the nervous system.

The result: overactive nerve signalling is calmed, and the intensity of shooting, burning, and stabbing pain is significantly reduced. The Sustained Release (SR) formulation in MAV-NT ensures a smooth, steady release of Pregabalin over time — delivering prolonged pain control with fewer peaks and troughs in blood concentration, which also reduces the risk of dizziness and sedation often seen with immediate-release formulations.

Nortriptyline 10mg — The Pain Signal Modulator

Nortriptyline is a tricyclic antidepressant (TCA) that works through a completely different mechanism from Pregabalin. It inhibits the reuptake of serotonin and norepinephrine in the central nervous system — increasing the availability of these neurotransmitters at nerve synapses. This enhances the body’s own descending pain inhibitory system, which naturally suppresses pain signals travelling from the peripheral nerves to the brain.

In MAV-NT, Nortriptyline at the low dose of 10mg is specifically calibrated to provide pain-modulating and mood-stabilising benefits without significant sedation or the anticholinergic side effects often associated with higher doses used in antidepressant therapy. It is particularly effective in treating the burning and allodynia (pain from non-painful stimuli) components of neuropathic pain.

Methylcobalamin 1500mcg — The Nerve Repair and Regeneration Agent

Methylcobalamin is the neurologically active form of Vitamin B12 — the most bioavailable form for nerve tissue. Unlike standard cyanocobalamin, Methylcobalamin is directly utilised by nerve cells without requiring metabolic conversion. It plays a critical role in:

• Myelin sheath synthesis — the protective fatty coating around nerve fibres that ensures fast, accurate signal transmission. In neuropathic conditions, the myelin sheath degenerates; Methylcobalamin supports its repair and regrowth.
• Axonal regeneration — actively promotes the repair and regeneration of damaged nerve axons, addressing the root structural cause of neuropathic pain rather than just masking symptoms.
• Homocysteine regulation — reduces elevated homocysteine levels in the blood, which is a known independent risk factor for nerve damage and cardiovascular disease.

At 1500mcg, Methylcobalamin in MAV-NT provides a therapeutic dose — not merely a supplementary one — ensuring real neuroprotective and nerve-regenerating activity.

Together, these three molecules in MAV-NT create a triple-layer approach: Pregabalin blocks the pain at the nerve channel level, Nortriptyline modulates pain signal transmission in the brain, and Methylcobalamin repairs the underlying nerve damage — making MAV-NT one of the most complete neuropathic pain management tablets available in the Indian pharmaceutical market.

Clinical Indications — What Conditions Does Nortriptyline, Pregabalin and Methylcobalamin Tablets Treat?

MAV-NT is prescribed by neurologists, orthopaedic surgeons, diabetologists, general physicians, and pain management specialists for a wide range of conditions:

1. Diabetic Peripheral Neuropathy (DPN): This is the single largest indication for this combination in India. Millions of diabetic patients develop nerve damage in their feet, legs, and hands over time — characterised by numbness, tingling, burning, and shooting pain. MAV-NT is a first-line prescription choice for managing DPN, as all three molecules target different aspects of the condition simultaneously.
2. Postherpetic Neuralgia (PHN): After a shingles (herpes zoster) infection resolves, many patients are left with severe, persistent nerve pain in the affected area. This post-herpetic neuralgia can last for months or years and is notoriously difficult to treat. Pregabalin + Nortriptyline is one of the most recommended combinations for PHN management.
3. Sciatica and Lumbar Radiculopathy: Compression or irritation of the sciatic nerve — causing shooting pain radiating from the lower back down the leg — is extremely common in orthopaedic practice. MAV-NT provides effective relief for the neuropathic component of sciatica and lumbar disc-related nerve pain.
4. Cervical and Lumbar Spondylosis with Neuropathy: Nerve root compression due to cervical or lumbar spondylosis causes radiating, burning pain in the arms or legs. MAV-NT is widely prescribed by orthopaedic surgeons and neurologists for these conditions.
5. Peripheral Neuropathy (Various Causes): Neuropathy arising from chemotherapy, alcoholism, autoimmune conditions, chronic kidney disease, or idiopathic causes responds well to the triple combination in MAV-NT.
6. Chronic Pain Syndromes with Neuropathic Component: Conditions like fibromyalgia, complex regional pain syndrome (CRPS), and chronic back pain with neuropathic features benefit from the multi-modal pain management approach offered by Pregabalin + Nortriptyline + Methylcobalamin.
7. Trigeminal Neuralgia and Facial Nerve Pain: Severe facial pain conditions like trigeminal neuralgia — often described as one of the most excruciating pain experiences — may be managed with Pregabalin-based combinations as part of a comprehensive treatment plan.
8. Vitamin B12 Deficiency with Neuropathy: Patients with B12 deficiency presenting with peripheral neuropathy, paraesthesia (pins and needles), or sensory disturbances benefit from the Methylcobalamin component in MAV-NT, which directly addresses the nutritional root cause of nerve dysfunction.

Why MAV-NT is a High-Demand Product for Your PCD Pharma Franchise

Neuropathic pain is one of the fastest-growing therapeutic segments in Indian pharma — and for good reason:

• Diabetes epidemic — India has over 100 million diabetic patients, and nearly 50% develop some form of diabetic neuropathy. This creates an enormous, growing, and permanent prescription base for neuropathic pain combinations like MAV-NT.
• Ageing population — As India’s population ages, the incidence of spondylosis, sciatica, postherpetic neuralgia, and peripheral neuropathy is rising sharply year on year.
• Multi-speciality prescriber base — MAV-NT is prescribed by neurologists, orthopaedic surgeons, diabetologists, general physicians, and pain specialists — giving PCD franchise partners access to a very wide doctor network in every territory.
• Chronic condition = repeat prescriptions — Neuropathic pain is a long-term condition. Patients on MAV-NT stay on it for months, often years — meaning automatic monthly reorders from your retail and stockist partners.
• Premium tablet category — Triple-combination neuropathic pain tablets command strong pricing with healthy margins for franchise partners.
• Proven prescription acceptance — The Pregabalin + Nortriptyline + Methylcobalamin combination has very high doctor familiarity and confidence, making it relatively easy to introduce to prescribers already familiar with similar FDCs.

PCD Pharma Franchise for Nortriptyline, Pregabalin and Methylcobalamin Tablets — Partner with Senen Biotech

Senen Biotech is offering an exclusive, monopoly-based PCD Pharma Franchise for MAV-NT across all states and union territories of India. If you want to build a strong neuro-ortho prescription portfolio with a product that has genuine, compounding demand, MAV-NT is the right product to anchor your franchise with.

What Senen Biotech Offers Its Franchise Partners:

• Exclusive monopoly territory rights — Your district or city is yours alone. No internal competition from other Senen Biotech franchise partners in your area.
• Full marketing and promotional support — Visual aids for doctor visits, product LBLs (leave-behind literature), prescription reminder cards, sample input cards, and product brochures — complete promotional toolkit provided.
• Competitive PTS/PTR pricing — Attractive profit margins at every level of the supply chain, from distributor to retailer.
• Pan-India dispatch — Timely delivery from the Panchkula facility directly to your location across all states.
• Full documentation and regulatory support — Drug licence guidance, product composition certificates, and batch analysis reports as required.
• Responsive partner support — A dedicated, transparent relationship with the Senen Biotech team for orders, stock updates, and business queries.

Dosage and Administration (For Reference Only — Physician Prescription Mandatory)

MAV-NT should be taken strictly as prescribed by the treating neurologist, orthopaedic surgeon, or general physician. The typical adult dosage is one tablet once or twice daily, depending on the severity of the condition and the patient’s response to therapy.

General Guidelines:

• Swallow the tablet whole with water — do not crush, break, or chew the SR tablet
• Preferably take after meals to reduce the chance of stomach discomfort
• Take at the same time each day for consistent therapeutic effect
• Do not stop the medication abruptly — dose tapering under physician supervision is recommended when discontinuing, particularly for Pregabalin
• Avoid alcohol during therapy, as it enhances CNS depression

Precautions and Contraindications

• Kidney impairment — Pregabalin is renally excreted. Dose adjustment is essential in patients with reduced kidney function. Physicians should check renal parameters before prescribing.
• Cardiac conditions — Nortriptyline can affect cardiac conduction. It should be used with caution in patients with a history of arrhythmias, recent heart attack, or heart block.
• Elderly patients — Both Pregabalin and Nortriptyline can cause increased sedation and fall risk in elderly patients. Use with care and start at the lowest effective dose.
• Pregnancy and breastfeeding — MAV-NT is not recommended during pregnancy or breastfeeding unless specifically prescribed by a physician after careful risk-benefit assessment.
• Driving and operating machinery — Pregabalin and Nortriptyline can impair alertness, reaction time, and concentration. Patients should be advised not to drive or operate heavy machinery until they know how MAV-NT affects them.
• History of substance abuse — Pregabalin has a potential for dependence. Use with caution in patients with a history of substance abuse.
• Glaucoma and urinary retention — Nortriptyline’s anticholinergic properties may worsen these conditions. Screen patients before prescribing.
• Drug interactions — MAV-NT may interact with CNS depressants, MAO inhibitors, other antidepressants, and antiepileptic drugs. A full medication review is recommended before starting therapy.

Possible Side Effects

MAV-NT is generally well-tolerated at prescribed doses. Common side effects, if they occur, include:

• Drowsiness or sedation (especially during the first week of therapy)
• Dizziness or light-headedness
• Dry mouth
• Weight gain (with prolonged use)
• Constipation
• Blurred vision (mild, usually transient)
• Peripheral oedema (mild ankle swelling — more common with Pregabalin at higher doses)

Most side effects are mild to moderate and tend to resolve as the body adjusts to the medication. Patients should be counselled to report any persistent or worsening symptoms to their physician immediately.

How to Apply for MAV-NT PCD Pharma Franchise

Starting your franchise partnership with Senen Biotech for MAV-NT is straightforward:

1. Reach out to Senen Biotech via phone, WhatsApp, or email
2. Share your territory and business details — district, city, and any existing pharma distribution setup
3. Receive the full product catalogue and PCD pricing list (PTR/PTS) for MAV-NT and other Senen Biotech products
4. Sign the franchise agreement and receive your exclusive monopoly territory confirmation
5. Place your first order and receive stock with a complete doctor-visit marketing support kit

Frequently Asked Questions (FAQs)

What is MAV-NT used for? 

MAV-NT (Pregabalin 75mg SR + Nortriptyline 10mg + Methylcobalamin 1500mcg) is a triple-combination tablet used to treat neuropathic pain conditions including diabetic peripheral neuropathy, postherpetic neuralgia, sciatica, cervical and lumbar spondylosis with nerve pain, and peripheral neuropathy of various causes.

How does MAV-NT work differently from a single-ingredient neuropathic pain tablet? 

MAV-NT uses three molecules that work through three separate mechanisms simultaneously — Pregabalin blocks the calcium channels in overactive pain-signalling nerves, Nortriptyline enhances the brain’s own pain-dampening system, and Methylcobalamin repairs and regenerates the damaged nerve cells. This triple-action approach is far more comprehensive and effective than any single molecule alone.

Can MAV-NT be taken long-term for chronic neuropathic pain? 

Yes, for chronic conditions like diabetic neuropathy, long-term use under medical supervision is common and appropriate. However, Pregabalin requires gradual dose tapering when discontinuing — patients should never stop abruptly without physician guidance.

Is MAV-NT safe for elderly patients? 

It can be used in elderly patients but with extra caution, as Pregabalin and Nortriptyline can increase sedation, fall risk, and cognitive effects in older individuals. The treating physician will typically start at the lowest effective dose and monitor closely.

Does MAV-NT cause addiction or dependence? 

Pregabalin has a known potential for dependence, particularly in patients with a history of substance abuse. MAV-NT is a Schedule H prescription medicine and must only be used strictly as directed by a qualified physician. It should not be self-medicated or obtained without a prescription.

Is PCD Pharma Franchise for MAV-NT available in my state? 

Yes. Senen Biotech offers monopoly-based PCD Pharma Franchise for MAV-NT across all states and union territories of India. Contact the team to confirm availability in your specific territory.

What is the packing of MAV-NT? 

MAV-NT comes in a 10×10 blister pack — 100 tablets per box — in the standard format preferred by stockists, distributors, and retail pharmacies across India.